Renny has over 15 years of expertise in the biopharmaceutical industry, with experience in antibody and biologics-based drug discovery, immunology, biochemistry, and protein engineering. From a team that includes inventors of Read this BioPharma Reporter article describing how our antibody discovery platform and downstream capabilities identifies the most viable therapeutic antibody candidate. Sorry, you need to enable JavaScript to visit this website. Charles River Laboratories International, Inc. (NYSE: CRL) announced today that it acquired of Distributed Bio, Inc. on December 31, 2020. engineering with big data, machine learning, and computational Charles River agreed to pay $83 million cash upfront, and up to $21 million in payments tied to achieving unspecified milestones. Our dedicated employees are focused on providing clients with exactly what they need to improve and expedite the discovery, early-stage development and safe manufacture of new therapies for the patients who need them. Our dedicated employees are focused on providing clients with exactly what they need to improve and expedite the discovery, early-stage development and safe manufacture of new therapies for the patients who need them. The. Distributed Bios computational immunology expertise also enables optimization of existing client antibodies generated through more traditional platforms, such as hybridoma or traditional phage display. At Distributed Bio, he grew the company from 3 to 30 people before completing the acquisition by Charles River in December 2020. Todd Spencer, 781-222-6455 providing clients with exactly what they need to improve and expedite 781.222.6455 Our mission is to disrupt biologic The proposed acquisition and associated fees have been financed through Charles Rivers existing revolving credit facility and cash. Charles River provides essential products and services to help In addition to the initial purchase price, the transaction includes contingent additional payments of up to $21 million based on future performance. Our dedicated employees are focused on providing clients with exactly what they need to improve and expedite the discovery, early-stage development and safe manufacture of new therapies for the patients who need them. Optimize your lead to introduce murine and cyno cross-reactivity as well as identify new leads that are species cross-reactive. Our dedicated employees are focused on providing clients with exactly what they need to improve and expedite the discovery, early-stage development and safe manufacture of new therapies for the patients who need them. The acquisition of Distributed Bio expands Charles Rivers scientific capabilities with an innovative, large-molecule discovery platform. Cision Distribution 888-776-0942 Later awarded a postdoctoral fellowship from the Swiss National Science Foundation, Kathrin joined the lab of Charles Craik at University of California San Francisco where her research focused on the generation of antibodies against complex membrane proteins. Charles River Laboratories International, Inc., is an American pharmaceutical company specializing in a variety of preclinical and clinical laboratory, gene therapy and cell therapy services for the Pharmaceutical, Medical device and Biotechnology industries. Distributed Bios antibody libraries and integrated antibody Bios antibody discovery platforms. At Distributed Bio, he grew the company from 3 to 30 people before completing the acquisition by Charles River in December 2020. WILMINGTON, Mass.-- ( BUSINESS WIRE )-- Charles River Laboratories International, Inc. (NYSE: CRL) announced today that it acquired of Distributed Bio, Inc. on December 31, 2020. With the Distributed Bio acquisition, Charles River now offers an integrated target to clinic portfolio including: California Life Sciences professionals discuss navigating the early stages of drug development in this roundtable with experts from Charles River SSF, Westlake Village BioPartners, Rubido Life Sciences, and Nitrome Biosciences. James C. Foster, Chairman, President and Chief Executive Officer of Charles River Laboratories, commented, The addition of Distributed Bios next-generation antibody discovery capabilities further enhances Charles Rivers unique ability to serve as a single-source partner to support our clients early-stage research. Todays newer approaches mean its not necessary to spend time and resources on humanization, sequencing, optimization. Our mission is to disrupt biologic It includes antibodies with no mutations in the framework. Our dedicated employees are focused on providing clients with exactly what they need to improve and expedite the discovery, early-stage development, and safe manufacture of new therapies for the patients who need them. Through our collaborative approach and comprehensive range of services, our experts accelerate timelines. Distributed Bios SuperHuman antibody libraries and integrated antibody optimization technologies help to enhance the probability of success for delivering high-quality, readily formattable antibody fragments to support antibody and cell and gene therapy candidates to biopharmaceutical clients. Charles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts. Antibody Humanization Your antibody is 'tumbled' through our proprietary technology, producing an antibody candidate that is identical to human antibody structure and behavior. Forward-looking statements include statements in this news release regarding the acquisition of Distributed Bio and Charles Rivers expectations with respect to the impact of Distributed Bio on the Company, its product and service offerings, client perception, revenue, revenue growth rates, and earnings per share; Charles Rivers projected future performance including revenue and earnings per share; as well as Charles Rivers future growth for discovery services. platforms and Charles Rivers downstream capabilitieswill deliver a the probability of success for delivering high-quality antibody The acquisition marks the culmination of an exclusive partnership between these companies that was initiated in October 2018. When typing in this field, a list of search results will appear and be automatically updated as you type. https://www.businesswire.com/news/home/20181025005076/en/. WILMINGTON, Mass.--(BUSINESS WIRE)-- Charles River Laboratories International, Inc. (NYSE: CRL) and Wheeler Bio, Inc., a contract development and manufacturing organization (CDMO), today announced an agreement to implement RightSource SM at Wheeler Bio's current good manufacturing practice (CGMP) biologics manufacturing facility in Oklahoma City, OK. By using AbGenesis to analyze thousands of antibody repertoires and antibody libraries, they developed the computationally optimized SuperHuman antibody discovery platform. This drug discovery platform technology creates a unique end-to-end platform for therapeutic antibody programs. & SAN FRANCISCO--(BUSINESS WIRE)--Oct. 25, 2018-- WILMINGTON, Mass.-- ( BUSINESS WIRE )--Charles River Laboratories International, Inc. (NYSE: CRL) announced today that it acquired of Distributed Bio, Inc. on December 31, 2020. Our successful partnership has already generated significant client interest and we believe our broader platform will continue to attract new discovery business opportunities. therapies for the patients who need them. From a team that includes inventors of Those risks and uncertainties include, but are not limited to, the ability to successfully integrate the acquisition of Distributed. A combination According to Charles River, Distributed Bios libraries are computationally optimized for both sequence diversity and immuno-engineering fitness based on analysis of thousands of human antibody repertoires and all known monoclonal antibodies in clinical trials, with the aim of generating several binding antibodies against every antigen tested. Todd Spencer This partnership will grant Charles Rivers clients access to the discovery, early-stage development and safe manufacture of new The SuperHuman antibody library and the Tumbler optimization technology identified antibodies shown by independent labs to completely block the novel coronavirus from infecting human cells. Strengthen your program Charles River Acquired Distributed Bio More Science WILMINGTON, Mass.-- ( BUSINESS WIRE )--Charles River Laboratories International, Inc. (NYSE: CRL) announced today that it acquired of Distributed Bio, Inc. on December 31, 2020. By adding innovative capabilities like large molecule discovery, we are enabling our clients to remain with one scientific partner from target identification through IND filing, and solidifying our position as the leading, early-stage contract research organization,Foster stated. WILMINGTON, Mass. Charles River Distributed Bios large-molecule discovery platform fills a gap in our portfolio and expands our early discovery expertise in a complex drug modality that few CROs can successfully offer. developed the computationally optimized SuperHuman antibody discovery from 8 AM - 9 PM ET. organization with a global reach and a track record of excellence. Distributed Bios computational immunology expertise also enables optimization of existing client antibodies generated through more traditional platforms, such as hybridoma or traditional phage display. Distributed Bio s computational immunology expertise also enables optimization of existing client antibodies generated through more traditional platforms, such as hybridoma or traditional phage display. Previously at Bristol-Myers Squibb Research Centre, she was a Discovery Biology Team Lead, responsible for early-stage discovery and preclinical progression of small molecules and therapeutic antibodies for oncology and immunology portfolios. The tightest affinity binders may not yield the most functional or safe molecule. In his current role as Client Manager, Shahrad works closely with clients and the Antibody Discovery operations teams to develop project proposals that outline clients specific antibody discovery or optimization campaigns in addition to providing technical knowledge to clients looking to perform antibody discovery and optimization with Charles River. amy.cianciaruso@crl.com. The acquisition marks the culmination of an exclusive partnership between these companies that was initiated in October 2018. Delivered clones from this antibody library will represent truly unique lead candidates. pharmaceutical and biotechnology companies, government agencies and As a result, CRL is paying a significant price, with a core USD 83m amount and USD 21m in earn-outs. provides our clients with Distributed Bios ability to discover new discovery and development. This Distributed Bio antibody discovery and optimization platform create a unique end-to-end platform for therapeutic antibody programs. President of Discovery and Safety Assessment at Charles River. The transaction combines Distributed Bios antibody libraries and immuno-engineering platform with Charles Rivers extensive drug discovery and non-clinical development expertise to create an integrated, end-to-end platform for therapeutic antibody and cell and gene therapy discovery and development. This large molecule discovery platform improves the chance of successful hit finding, reduces optimization requirements, and thereby expedites the antibody discovery process by several months. monoclonal generation technologies by generating a staggering number of faster than before. -, Charles River is the premier, early-stage contract research antibody repertoire sequencing technologies, their AbGenesis antibody 781.222.6455 We believe our clients willingness to outsource more of their discovery programs will be predicated on our ability to continue to add innovative capabilities to meet our clients critical research needs, which we are accomplishing through strategic acquisitions and our partnership strategy. Charles River Laboratories International, Inc. (NYSE: CRL) today Corporate Vice President, Investor Relations A combination The transaction combines Distributed Bios antibody libraries and immuno-engineering platform with Charles Rivers extensive drug discovery and non-clinical development expertise to create an integrated, end-to-end platform for therapeutic antibody and cell and gene therapy discovery and development. During her academic career, she worked as a Post-Doctoral Fellow at the Massachusetts Institute of Technology (MIT), USA, focusing on regulatory proteins and gene editing. comprehensive research experience from idea to clinic. Distributed Bios libraries are Corporate Vice President, Investor Relations James C. Foster, Chairman, President and Chief Executive Officer of Charles River Laboratories, commented, The addition of Distributed Bios next-generation antibody discovery capabilities further enhances Charles Rivers unique ability to serve as a single-source partner to support our clients early-stage research. Forward-looking statements are based on Charles Rivers current expectations and beliefs, and involve a number of risks and uncertainties that are difficult to predict and that could cause actual results to differ materially from those stated or implied by the forward-looking statements. Media Contacts: Charles River Laboratories plans to acquire the cell and gene therapy contract development and manufacturing organization (CDMO) Cognate BioServices for approximately $875 million cash, in a. A further description of these risks, uncertainties, and other matters can be found in the Risk Factors detailed in Charles River's Annual Report on Form 10-K as filed on February 11, 2020 and the Quarterly Report on Form 10-Q as filed on October 29, 2020, as well as other filings we make with the Securities and Exchange Commission. The purchase price was $83 million in cash, subject to customary closing adjustments. She holds a PhD in biochemistry and biophysics from the Tata Institute of Fundamental Research (TIFR), India. As the site head at South San Francisco, at the former Distributed Bio location, he has overall responsibility for all aspects of antibody discovery. The acquisition of Distributed Bio expands Charles River s scientific capabilities with an innovative, large-molecule discovery platform. Does this antibody library have success with challenging target classes such as GPCRs? Deployed on-site at a client's facility, RightSourceSM is a flexible biologics testing lab operated and managed by Charles River, making fast, reliable quality control (QC) more accessible to a broader reach of companies like Wheeler Bio. The proposed acquisition and associated fees have been financed through Charles Rivers existing revolving credit facility and cash. Caution Concerning Forward-Looking Statements. Given the number of Our successful partnership has already generated significant client interest and we believe our broader platform will continue to attract new discovery business opportunities, James C. Foster, chairman, president, and CEO of Charles River Laboratories, said in a statement. Charles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts. 2023 Charles River Laboratories. Bios antibody discovery platforms. Receive the latest news and insights to your inbox. WILMINGTON, Mass. analyze antibody repertoires by high-throughput sequence, sanger The SuperHuman antibody library is suited for all target classes including ion channels, GPCRs, anti-ids, HIV, allosterics, and anti-pMHCs but is especially well-suited for CARs. In a tweet January 4, Glanville said Centivax will continue to develop those and other products following Distributed Bio's sale to Charles River Labs: "@CRiverLabs acquires my first venture . Quickly discover, analyze, and engineer therapeutic antibodies with our comprehensive antibody discovery platforms. hits against all targets tested, including GPCRs. process to as little as three to four months. Working with our team gives you access to decades of antibody and other large molecule discovery experience to help guide your antibody program to the clinic with the greatest chance of success. The acquisition marks the culmination of an exclusive partnership between these companies that was initiated in October 2018. This large molecule discovery platform improves the chance of successful hit finding, reduces optimization requirements, and thereby expedites the antibody discovery process by several months. Founding Partner and CEO Todd SpencerCorporate Vice President, Investor Relations 2023 Charles River All rights reserved. Now at Charles River, Dr. Buerckert functions as Director of Bioinformatics for large molecule discoveries heading the antibody engineering and R&D efforts in South San Francisco. Dr. Moiset has a combined background in immunology, cellular biology, and medicinal chemistry. January 6, 2021 By Bio-IT World Staff January 6, 2021 | On the first Monday of the new year, Charles River Laboratories announced its acquisition of Distributed Bio on December 31, 2020. Forward-looking statements may be identified by the use of words such as anticipate, believe, expect, will, may, estimate, plan, outlook, and project and other similar expressions that predict or indicate future events or trends or that are not statements of historical matters. finding, reduces optimization requirements, and expedites the discovery client antibodies generated through more traditional platforms, such as Our platform delivers 50 binders with a range of affinities (single to double-digit nM with pM potential) selected from a pool of 300-500 confirmed hits. Distributed Bio is a computational immunoengineering biotechnology group, self-funded by licensing a stack of technologies to partners across the pharmaceutical industry. SuperHuman overcomes many of the limitations of other monoclonal generation technologies by generating a staggering number of hits against all targets tested, including GPCRs. 2023 Charles River Laboratories. Along with antibody discovery work (HT affinity screen, epitope binning), Kalyani also has experience with SPR-based characterization of bispecifics, ADCs, Fc engineering, and Ab stressed samples. Our dedicated employees are focused on Distributed Bio is a computational immunoengineering biotechnology In addition to our Antibody Discovery Team, working with Charles River gives you access to our comprehensive Scientific Advisory Services Team. Mit Ihrer Anmeldung erklren Sie sich damit einverstanden, Inhalte von uns zu erhalten. To ensure the most secure and best overall experience on our website, we recommend the latest versions of, antibody Wheeler Bio provides its clients with access to an innovative manufacturing platform called Portable CMC, which is coupled with Leap-In Transposase (ATUM) and a layer of digital solutions to accelerate timelines from discovery to IND. Powered by Madgex Job Board Software, https://www.businesswire.com/news/home/20181025005076/en/, http://www.businesswire.com/news/home/20181025005076/en. Distributed Bios libraries are computationally optimized for both sequence diversity and engineering fitness through the analysis of thousands of human antibody repertoires and all known monoclonal therapeutics in clinical trials. Accelerate Drug Discovery with Integrated Data and AI, Recent Advances in Targeting the Microbiome in Colitis, Next Generation ASOs for Muscular Dystrophy, How AI Is Driving Innovation and De-Risking R&D, Charles River Completes Acquisition of SAMDI Tech, Physical Characterization & Pharmaceutical Sciences, Biologics Discovery and Protein Engineering, Phage Antibody Discovery and Antibody Engineering, Cosmic Antibody Library for Antibody Discovery, SuperHuman Antibody Library for Antibody Discovery, Tungsten VHH Library for Nanobody Discovery, Scientific and Regulatory Advisory Services, Agrochemical Testing Services for Approvals, Our Commitment to Diversity, Equity & Inclusion. Distributed Bios large-molecule discovery platform fills a gap in our portfolio and expands our early discovery expertise in a complex drug modality that few CROs can successfully offer. Based in South San Francisco, California, Distributed Bio is a next-generation antibody discovery company. engineering with big data, machine learning, and computational hybridoma or traditional phage display. Jan 04 2021 Charles River Acquires Distributed Bio The past two years spent in partnership with Distributed Bio have resulted in some groundbreaking science, collaboration, and discoveries for our clients, most recently in the therapeutic antibody space. platform. optimization technologies. His PhD thesis at ETH Zurich in biochemistry and biophysics was on protein folding, stability, and structural biology. -- (BUSINESS WIRE)-- Charles River Laboratories International, Inc. (NYSE: CRL) announced today that it acquired of Distributed Bio, Inc. on December 31, 2020. partner that had both the scale to match our growth and the agility to All rights reserved. At Charles River, Ed works with the team to develop offerings in the antibody space, building upon existing approaches to enable a comprehensive biologic offering. Investor Contact:Charles RiverTodd todd.spencer@crl.com "On-site support by the industry's leading testing provider adds considerable value to our growing base of clients advancing important therapeutic antibodies and other biologics into human trials for the first time.". optimization technologies. libraries that can generate more than 5,000 unique hits against every computationally optimized for both sequence diversity and engineering How does the SuperHuman antibody library avoid immunogenicity liabilities. hits, this library can be panned under unprecedented aggressive isolating multi-species cross-reactive members against target homologs Distributed Bio is an example of our selective technology investments potentially becoming acquisitions after working with the target company for a meaningful period of time to provide its services to our clients. As you continue to work with the Distributed Bio experts, scientists, and contacts you know and trust, youll also have access to Charles Rivers team of industry-leading scientists who excel at guiding large molecule development from lead discovery to IND. New partnership allows Charles Rivers clients access to Distributed Source: Charles River Laboratories International, Inc. View this news release online at: After a two-year partnership, early-stage CRO Charles River Labs has decided to buy out next-gen antibody discovery company Distributed Bio. 2023 Charles River Laboratories. Sorry, you need to enable JavaScript to visit this website. Distributed Bios libraries are computationally optimized for both sequence diversity and immuno-engineering fitness through the analysis of thousands of human antibody repertoires and all known monoclonal therapeutics in clinical trials, which can generate many unique binders against every antigen tested. monoclonal generation technologies by generating a staggering number of Stringently select for binders that distinguish as little as a single-AA difference between on-target and off-target effects. To learn more about our unique portfolio and breadth of services, visit www.criver.com. ensures that our portfolio is truly next generation. The acquisition comes five months after Charles River Labs bought Cellero, a cell therapy company in Memphis, for $38 . Charles River is the premier, early-stage contract research organization with a global reach and a track record of excellence. Wheeler Bio and Charles River will work in close collaboration to set up a cGMP testing lab at Wheeler Bio's ultra-modern Oklahoma City facility. 1. Learn more about the Scientific Advisory Services Team. He graduated from the Kaiserslautern University in Germany, working on small molecule drug discovery, and later obtained his PhD from the Luxembourg Institute of Health. BioGiles DayFounding Partner and CEOgiles@distributedbio.com, Charles River Corporate Citizenship ReportView PDFPrint PDF, Charles River and Distributed Bio Enter Exclusive Partnership to Create an Integrated Antibody Discovery and Development Platform. investments or local bioinformatics specialists. Charles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts. We are pleased to welcome Distributed Bio to the Charles River family.. Distributed Bios computational immunology expertise is also designed to enable optimization of existing client antibodies generated through more traditional platforms, such as hybridoma or traditional phage display. http://www.businesswire.com/news/home/20210104005198/en, 1985 - 2023 BioSpace.com. Jake Glanville, Ph.D., Founding Partner and Chief Science Officer at The companies created a combined antibody discovery and development platform for Charles River Labs clients that integrated Distributed Bios libraries and optimization technologies with Charles Rivers expertise in early-stage drug discovery services. hits against all targets tested, including GPCRs. Leads are perfect for IgGs, CAR-Ts, bi-specifics, ADCs, and nanobody applications. Studies indicate a more stable binder can reduce tonic signaling. Distributed Bios computational immunoengineering platform provides candidates. & SAN FRANCISCO--(BUSINESS WIRE)-- Charles River Laboratories International, Inc. (NYSE: CRL) today announced that it has entered into an exclusive partnership with Distributed Bio, Inc., a leader in the computational design and optimization of antibody discovery platforms. Distributed Bio is an immuno-engineering company that provides computational tools, antibody libraries, and more. drug development expertise will create a unique end-to-end platform for across the pharmaceutical industry. realize the value of our antibody platforms as fast as possible. - Shahrads background is in antibody design and engineering with a focus on phage-display antibody libraries stemming from his time at Distributed Bio where he worked for three years, leading the Antibody Optimization and Affinity Maturation programs. Antibody engineering advances have allowed for the fastest, most diverse, and optimized discovery. This press release features multimedia. We believe our clients willingness to outsource more of their discovery programs will be predicated on our ability to continue to add innovative capabilities to meet our clients critical research needs, which we are accomplishing through strategic acquisitions and our partnership strategy. This news release includes forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Distributed Bio is an example of our selective technology investments potentially becoming acquisitions after working with the target company for a meaningful period of time to provide its services to our clients. With its focus on speed and design efficiency, we believe the acquisition of Distributed Bio will enable us to build upon the more than 80 novel small molecule candidates that we have discovered for our clients and meet our goal of eliminating an additional year from our clients early-stage development timelines. Dr. Namrata Jayanth is a Research Leader at the Early Discovery site in Leiden, Netherlands. Distributed Bio officially joined the Charles River Discovery team as of January 1, 2021, creating an unmatched, seamless service for your therapeutic antibody discovery and development. To learn more about our unique portfolio and breadth of services, visit www.criver.com. Distributed Bio is a computational immunoengineering biotechnology conditions, recovering hundreds of subnanomolar binders in under a week, Maurice studied biochemistry at the University of Zurich where he worked in Andreas Plckthuns laboratory on antibodies. We are also looking into a way to enable investment by the masses through NetCapital.. The SuperHuman synthetic antibody library technology for antibody discovery delivers more monoclonal antibody hits in less lead discovery and development time than hybridoma, traditional phage and transgenic methods. Antibody discovery with us can take as little as two months to target specific single-chain antibodies or nanobodies. The transaction is not expected to have a material impact on Charles Rivers GAAP or non-GAAP financial results in 2021. 781.222.6168 In January 2020, as COVID-19 began to wreak havoc on the world, Distributed Bio and its CEO, president, and chairman Jacob Glanville, PhD, were featured in the first season of Netflixs Pandemic: How to Prevent an Outbreak, focused on efforts by doctors, researchers, healthcare workers, and public health officials to fight influenza and future global pandemics. immunology-driven design. analyze thousands of antibody repertoires and antibody libraries, they This partnership will grant Charles Rivers clients access to WILMINGTON, Mass. We are pleased to welcome Distributed Bio to the Charles River family.. Watch this animated video to see how a client first panned yeast display, then phage display, and finally mice models with no promising results. fitness through the analysis of thousands of human antibody repertoires In a tweet Monday, Glanville said Centivax will continue to develop those and other products: @CRiverLabs acquires my first venture, @distributedbio! Amy Cianciaruso, 781-222-6168 Considerations of an Antibody Library for CAR-T Applications. and all known monoclonal therapeutics in clinical trials. and drug development efforts. or Source: Charles River Laboratories International, Inc. Charles River Corporate Citizenship ReportView PDFPrint PDF, Charles River Laboratories Acquires Distributed Bio. immunology-driven design. She holds a PhD in Life Sciences from the University of Groningen and Zernike Institute for Advanced Materials. New partnership allows Charles Rivers clients access to Distributed Distributed Bios large-molecule discovery platform fills a gap in our portfolio and expands our early discovery expertise in a complex drug modality that few CROs can successfully offer. Distributed Bios libraries are computationally optimized for both sequence diversity and immuno-engineering fitness through the analysis of thousands of human antibody repertoires and all known monoclonal therapeutics in clinical trials, which can generate many unique binders against every antigen tested. With a focus on speed and design, this partnership will help increase hits, this library can be panned under unprecedented aggressive To learn more about our unique portfolio and breadth of services, visit www.criver.com. candidates. The SuperHuman antibody library is a synthetic antibody library computationally optimized for diversity and developability. The library allows for the function, safety risks, efficacy, and speed uniquely specified for CAR-T applications. Charles River is the premier, early-stage contract research Wheeler Bio's hub-and-spoke operating model connects coastal innovators with translational CMC services that are thoughtfully aligned with clients' business needs and fundraising strategies. By adding innovative capabilities like large molecule discovery, we are enabling our clients to remain with one scientific partner from target identification through IND filing, and solidifying our position as the leading, early-stage contract research organization, Mr. Foster concluded. Distributed Bio's libraries are computationally optimised for both sequence diversity and engineering fitness through the analysis of thousands of human antibody repertoires and all known . Distributed Bio's estimated annual revenue in 2020 was about $15 million. Charles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts. With a focus on speed and design, this partnership will help increase the probability of success for delivering high-quality antibody candidates. As the site head at South San Francisco, at the former Distributed Bio location, he has overall responsibility for all aspects of antibody discovery. Solid start to 2021., In response to a tweet questioning if that will result in accelerated antibody development, Glanville replied: Helps us focus on them 100% and means I can invest personally in their success. without additional engineering. 781.222.6168 Based in South San Francisco, California, Distributed Bio is a next-generation antibody discovery company. To ensure the most secure and best overall experience on our website we recommend the latest versions of, Internet Explorer is no longer supported. WILMINGTON, Mass. therapies for the patients who need them. Media: View source version on businesswire.com: https://www.businesswire.com/news/home/20181025005076/en/. To learn more about our unique portfolio and breadth of services, visitwww.criver.com. Forward-looking statements include statements in this news release regarding the acquisition of Distributed Bio and Charles Rivers expectations with respect to the impact of Distributed Bio on the Company, its product and service offerings, client perception, revenue, revenue growth rates, and earnings per share; Charles Rivers projected future performance including revenue and earnings per share; as well as Charles Rivers future growth for discovery services. Charles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts. The value of that partnership has not been disclosed. Formerly, she worked in biotech contributing to the development of monoclonal antibodies against cancer from discovery until IND submission. [2] Our mission is to. antigen tested. For this purpose, an RBD-Fc-Avi tag . Shahrad has been awarded six US Patents for his work in engineering COVID-19 neutralizing monoclonal antibodies. There is no longer a need to go to nonhuman antibodies to target GPCRs. comprehensive research experience from idea to clinic. This is important to control unwanted immune cell activation. group, self-funded by licensing a stack of technologies to partners Our mission is to disrupt biologic engineering with big data, machine learning, and computational immunology-driven design. The acquisition marks the culmination of an exclusive partnership between these companies that was initiated in October 2018. platforms and Charles Rivers downstream capabilitieswill deliver a Forward-looking statements are based on Charles Rivers current expectations and beliefs, and involve a number of risks and uncertainties that are difficult to predict and that could cause actual results to differ materially from those stated or implied by the forward-looking statements. Internet Explorer presents a security risk. Source: Charles River Laboratories International, Inc. Investor Contact:Charles RiverTodd hybridoma or traditional phage display. The idea is to create an integrated, end-to-end platform for therapeutic antibody and cell and gene therapy discovery and development, said the CRO. Leveraging our revolutionary antibody discovery and engineering In addition to the initial purchase price, the transaction includes contingent additional payments of up to $21 million based on future performance. Charles River Laboratories International, Inc.(NYSE: CRL) today announced the Company will provide clients exclusive access to the new Cosmic antibody library launched by Distributed Bio, Inc., a global leader in computational optimization of fully human monoclonal antibody libraries. The SuperHuman fully human phage display antibody library is comprised of 76 billion unique fully human antibodies with the diversity to deliver therapeutic leads in discovery against the hardest targets, including GPCRs, ion channels, pMHC complexes, anti-HIV bnAbs, allosteric modulators, mouse/human cross-reactive epitopes, anti-idiotypics, an. Charles River provides essential products and services to help faster than before. - Birgit Girshick, Corporate Executive Vice of Distributed Bios antibody libraries and Charles Rivers extensive About Wheeler Bio Wheeler Bio is a biomanufacturing pioneer, founded by a team of industry experts and strategic investors who believe a different CDMO model is needed to help innovators reach their clinical milestones faster. Distributed Bios estimated annual revenue in 2020 was approximately $15 million. -- (BUSINESS WIRE)--May 17, 2021-- Charles River Laboratories International, Inc. (NYSE: CRL) announced today that it has signed a definitive agreement to acquire Vigene Biosciences, Inc., a premier, U.S. -based gene therapy contract development and manufacturing organization (CDMO) providing viral vector-based gene delivery so. Our phage-based antibody libraries and Tumbler optimization platform were developed from the antibody expertise at Distributed Bio, and were acquired by Charles River in 2021. With its focus on speed and design efficiency, we believe the acquisition of Distributed Bio will enable us to build upon the more than 80 novel small molecule candidates that we have discovered for our clients and meet our goal of eliminating an additional year from our clients early-stage development timelines. providing clients with exactly what they need to improve and expedite Gemma leads the Cell Therapy team, contributing to early-stage research and discovery programs for novel drug therapies such cell therapies and therapeutic antibodies. Learn more about our integrated target-to-clinic biologics portfolio: In 1986, the US FDA approved the first mAb to limit organ transplant rejection. Distributed Bios computational immunoengineering platform provides libraries that can generate more than 5,000 unique hits against every antigen tested. leading academic institutions around the globe accelerate their research Dr. Zuberbhler joined Distributed Bio, now part of the . GEN Genetic Engineering and Biotechnology News, Charles River Labs Acquires Antibody Partner Distributed Bio for Up to $104M, Sepsis Biomarker Prospect Found in Sugar-Binding Protein, Weighing for Viral Capsids Wins Best New Technology Award, StockWatch: Nvidia Rides AI Wave to 180% Stock Surge, Brooks Instrument Joins Regenerative Drug Manufacturing Consortium, Massive Reference Genome Project Characterizes Primate Variation, Life Sciences M&A: Drivers and Market Outlook, Antioxidant Enzymes Come to the Rescue of DNA Damage, Parkinsons Disease Drug Slows ALS Progression in Clinical Trial, Viruses Are a Primary Driver of Human Evolution, MERS: Getting a Handle on a Serious Zoonotic Coronavirus Infection. SuperHuman overcomes many of the limitations of other All rights reserved. discovery and development. Corporate Vice President, Public Relations The result is key engineering guidance and optimization of every hit right out of the synthetic antibody library. antibody repertoire sequencing technologies, their AbGenesis antibody View the full release here: James C. Foster, Chairman, President and Chief Executive Officer of Charles River Laboratories, commented, The addition of Distributed Bios next-generation antibody discovery capabilities further enhances Charles Rivers unique ability to serve as a single-source partner to support our clients early-stage research. Wheeler Bio's technology platform, Portable CMC, simplifies the path between drug discovery and clinical manufacturing by providing a new bridge for translating discoveries to IND filing. Prior to starting DBio, Giles spent 15 years with Pfizer as bioinformatics scientist at the Sandwich Discovery site, and as Head of Informatics for the Biotherapeutics and Bioinnovation Center in San Francisco with a six-year stay at Pfizers Discovery Technology Center in Cambridge, MA in between. libraries that can generate more than 5,000 unique hits against every the probability of success for delivering high-quality antibody , , , , , , Environmental, Social and Governance (ESG), HVAC (Heating, Ventilation and Air-Conditioning), Machine Tools, Metalworking and Metallurgy, Aboriginal, First Nations & Native American, Wheeler Bio Announces Closing of $31 Million Series A Round Supporting its Clinical (CGMP) Drug Substance Manufacturing Facility in Oklahoma City. without additional engineering. provides our clients with Distributed Bios ability to discover new partner that had both the scale to match our growth and the agility to antibodies, then proceed seamlessly from hit to clinical candidate The dealcompleted Thursday and announced Mondaycame more than two years after the companies launched an exclusive partnership in October 2018. All rights reserved. To learn more about our unique The acquisition of Distributed Bio expands Charles Rivers scientific capabilities with an innovative, large-molecule discovery platform. WILMINGTON, Mass. Distributed Bios Given the number of , . analyze thousands of antibody repertoires and antibody libraries, they This partnership will grant Charles Rivers clients access to Distributed Bios antibody libraries and integrated antibody optimization technologies. After post-doc, Maurice moved to industry as a bioanalytics laboratory head at Cytos Biotechnology, followed by Abbott Laboratories and Bio-Rad before joining Charles River. In 2018, Distributed Bio entered into an exclusive partnership with Charles River, a leading provider of essential products and services for pharmaceutical and biotechnology companies, government . Distributed Bio, therefore, brings expertise to large molecule-hungry biotechs and complemented its small molecule capabilities. Immunogenicity doesnt manifest itself until human trials. Distributed Bio is a computational immunoengineering biotechnology group, self-funded by the success of the stack of antibody discovery, optimization and analysis technologies to partners. Distributed Bios libraries are computationally optimized for both sequence diversity and immuno-engineering fitness through the analysis of thousands of human antibody repertoires and all known monoclonal therapeutics in clinical trials, which can generate many unique binders against every antigen tested. En vous inscrivant la newsletter, vous consentez la rception de contenus de notre part. Charles River said it financed the acquisition and associated fees through its existing revolving credit facility and cash. What can Antibody Optimization do for Your Antibodies? Receive the latest news and insights to your inbox. drug development expertise will create a unique end-to-end platform for Spencer, 781-222-6455Corporate Vice President, Investor Relationstodd.spencer@crl.comorMedia Contact: Jesse McCool (405) 279-6767 [emailprotected]. This platform improves the chance of successful hit Amy Cianciaruso Cianciaruso, 781-222-6168Corporate Vice President, Public Relationsamy.cianciaruso@crl.comorDistributed "The RightSourceSM business model significantly reduces upfront lab set up costs, shields the client from the regulatory burden of managing a QC lab, and allows for leveraging our robust scientific expertisedirectly where clients need it most," said Ian Wyllie, Director Operations, RightSourceSM, Charles River. Corporate Vice President, Public Relations CDRH3s on confirmed binders for the last 20 programs were on average 9.7 amino acids apart from each other, all of which yielded over 50 lead candidates. We believe our clients willingness to outsource more of their discovery programs will be predicated on our ability to continue to add innovative capabilities to meet our clients critical research needs, which we are accomplishing through strategic acquisitions and our partnership strategy, Foster added. Acquired by Charles River Laboratories International South San Francisco, California, United States 11-50 Private www.distributedbio.com/ 207,808 Highlights Contacts 3 Employee Profiles 3 Similar Companies 6 Watch the video, Avoid common failures in late-preclinical and clinical stages of CAR oncology programs by conducting the right early discovery studies. Traditional phage display biopanning, along with approaches that have been around for a long time such as transgenic and hybridoma, are not ideal because they result in less hits in a greater amount of time. From a team that includes inventors of antibody repertoire sequencing technologies, their AbGenesis antibody and TCR repertoire analysis and engineering platform enables partners to analyze antibody repertoires by high-throughput sequence, sanger sequence, and functional assay without requiring large datacenter investments or local bioinformatics specialists. finding, reduces optimization requirements, and expedites the discovery For Further Information: Wheeler Bio, Inc. This phage display antibody library includes only frameworks with dominant alleles found in all human populations in addition to CDR diversity that contains only the variations that the human body can produce. and TCR repertoire analysis and engineering platform enables partners to View the full release here: https://www.businesswire.com/news/home/20181025005076/en/. In addition to the initial purchase price, the transaction includes contingent additional payments of up to $21 million based on future performance. Because forward-looking statements involve risks and uncertainties, actual results and events may differ materially from results and events currently expected by Charles River, and Charles River assumes no obligation and expressly disclaims any duty to update information contained in this news release except as required by law. With a focus on speed and design, this partnership will help increase About Charles River Charles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts. Our dedicated employees are focused on providing clients with exactly what they need to improve and expedite the discovery, early-stage development and safe manufacture of new therapies for the patients who need them. Wheeler's novel hub-and-spoke operational model, centered in the biomanufacturing metro ofOklahoma City, and integrated with biotechs and discovery CROs, will revolutionize the speed of drug development. He is currently the Head of Large Molecule Research for our South San Francisco Antibody Discovery site, the legacy Distributed Bio location. This combination All Rights Reserved. WILMINGTON, Mass. the discovery, early-stage development and safe manufacture of new View source version on businesswire.com: https://www.businesswire.com/news/home/20210104005198/en/, Investors: release the third generation of our discovery platform and sought a This partnership will grant Charles River's clients access to Distributed Bio's antibody libraries and integrated antibody optimisation technologies. Scientific and Regulatory Advisory Services, Agrochemical Testing Services for Approvals, Our Commitment to Diversity, Equity & Inclusion, Screening and Profiling Including Retrogenix Cell Microarray Assays, Charles River Presents: The Drug Discovery Journey. Charles River said the acquisition is not expected to have a material impact on its GAAP or non-GAAP financial results in 2021. release the third generation of our discovery platform and sought a Ed is an immunologist with over 20 years of experience, specializing in vaccine antigen and adjuvant design. To learn more about our unique investments or local bioinformatics specialists. Distributed Bios SuperHuman antibody libraries and integrated antibody optimization technologies help to enhance the probability of success for delivering high-quality, readily formattable antibody fragments to support antibody and cell and gene therapy candidates to biopharmaceutical clients. pharmaceutical and biotechnology companies, government agencies and realize the value of our antibody platforms as fast as possible. -. of Distributed Bios antibody libraries and Charles Rivers extensive This combination across the pharmaceutical industry. Avoid risks in your translational studies related to using surrogate molecules. therapeutic antibody Kalyani is a protein biochemist with extensive industry experience in antibody biophysical characterization and assay development with special focus on biosensor/label-free methodologies. announced that it has entered into an exclusive partnership with Distributed Source: Charles River Laboratories International, Inc. View this news release and multimedia online at: Those risks and uncertainties include, but are not limited to, the ability to successfully integrate the acquisition of Distributed. This human antibody library was designed with about five billion CDR-H3s but 76 billion total antibodies. giles@distributedbio.com. By signing up you agree to receive content from us. fitness through the analysis of thousands of human antibody repertoires Charles River offers this discovery platform to discover humanized antibodies against any target of interest including GPCRs and CARs. sequence, and functional assay without requiring large datacenter analyze antibody repertoires by high-throughput sequence, sanger Distributed Bio is a computational immunoengineering biotechnology group, self-funded by licensing a stack of technologies to partners across the pharmaceutical industry. When compared with mouse immunization, our proprietary SuperHuman phage display library enables rapid scFv and VHH discovery. http://www.businesswire.com/news/home/20181025005076/en, 1985 - 2023 BioSpace.com. Innovators benefit from increased momentum during technology transfer, shorter timelines, reduced risk, and lower costs. The acquisition of Distributed Bio expands Charles Rivers scientific capabilities with an innovative, large-molecule discovery platform. Corporate Vice President, Public Relations This platform-based satellite lab will be operated by Charles River employees who will utilize Charles River's quality management systems, test methods, and standard operating procedures (SOPs) to support all QC testing needs for Wheeler Bio. portfolio and breadth of services, visit www.criver.com. Todd Spencer Distributed Bios Distributed Bios computational immunoengineering platform provides We are about to Because forward-looking statements involve risks and uncertainties, actual results and events may differ materially from results and events currently expected by Charles River, and Charles River assumes no obligation and expressly disclaims any duty to update information contained in this news release except as required by law. Establishes a Premier, Integrated, Large Molecule Discovery Platform , Advances Exclusive Partnership Initiated in 2018 . This news release includes forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Caution Concerning Forward-Looking Statements. The transaction is not expected to have a material impact on Charles Rivers GAAP or non-GAAP financial results in 2021. With its focus on speed and design efficiency, we believe the acquisition of Distributed Bio will enable us to build upon the more than 80 novel small molecule candidates that we have discovered for our clients and meet our goal of eliminating an additional year from our clients early-stage development timelines. todd.spencer@crl.com recovering saturating coverage of hits against every epitope tested, and Distributed Bios computational immunology expertise also enables optimization of existing client antibodies generated through more traditional platforms, such as hybridoma or traditional phage display. Investors: Glanville and Distributed Bio were featured in the Netflix docuseries for their efforts to develop a broad-spectrum universal vaccine technology. and all known monoclonal therapeutics in clinical trials. View source version on businesswire.com: https://www.businesswire.com/news/home/20210104005198/en/, Investors: Distributed Bios estimated annual revenue in 2020 was approximately $15 million. The proposed acquisition and associated fees have been financed through Charles Rivers existing revolving credit facility and cash. This combination provides our clients with Distributed Bios ability to discover new antibodies, then proceed seamlessly from hit to clinical candidate faster than before. - Birgit Girshick, Corporate Executive Vice President of Discovery and Safety Assessment at Charles River. While the CDR-H3 and V-gene frameworks define much of a clones interaction with the target, variations in the other CDRs can impact affinity and breadth of reactivity. All rights reserved. Spencer, 781-222-6455Corporate Vice President, Investor Relationstodd.spencer@crl.comorMedia antibody discovery platforms. The commercial SuperHuman 2.0 Phage library (Distributed Bio/Charles River Laboratories) was used to identify monoclonal antibody binders to the SARS-CoV-2 RBD. Charles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts. The client eventually found success using the SuperHuman library. Leveraging our revolutionary antibody discovery and engineering platforms and Charles Rivers downstream capabilitieswill deliver a comprehensive research experience from idea to clinic. The deal combines Distributed Bio's antibody libraries and immuno-engineering platform with Charles River's drug discovery and non-clinical development expertise. This news release includes forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. To learn more about our unique portfolio and breadth of services, visit www.criver.com. This discovery platform successfully generated hits against the class A GPCR CXCR5 and has optimized hits against another (undisclosed) GPCR. & SAN FRANCISCO--(BUSINESS WIRE)--Charles River Laboratories International, Inc. (NYSE: CRL) today Sorry, you need to enable JavaScript to visit this website. developed the computationally optimized SuperHuman antibody discovery Based in South San Francisco, California, Distributed Bio is a next-generation antibody discovery company. Kathrin received her PhD in Applied Biosciences from the Swiss Federal Institute of Technology (ETH Zurich). Sign up to get PRNs top stories and curated news delivered to your inbox weekly! Prior to this, she was a joint Post-Doctoral Fellow with the University of Cambridge, UK and InStem, India, studying signaling proteins in cancer pathways. Distributed Bio Amy Cianciaruso We are about to release the third generation of our discovery platform and sought a partner that had both the scale to match our growth and the agility to realize the value of our antibody platforms as fast as possible. - Jake Glanville, Ph.D., Founding Partner and Chief Science Officer at Distributed Bio. portfolio and breadth of services, visit www.criver.com. All rights reserved. https://www.businesswire.com/news/home/20210104005198/en/, Our Commitment to Diversity, Equity & Inclusion. Prior to that, she was a post-doctoral fellow at the Netherlands Cancer Institute. amy.cianciaruso@crl.com, Endotoxin-free ClearColi Expression System, Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF), Pichia GlyoSwitch Protein Expression System, VIMPAT (lacosamide) for Treatment of Epileptic Seizures. and drug development efforts. Class a GPCR CXCR5 and has optimized hits against the class a CXCR5! 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